Functional coding variation in recombinant inbred mouse lines reveals multiple serotonin transporter-associated phenotypes
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چکیده
منابع مشابه
Functional coding variation in recombinant inbred mouse lines reveals multiple serotonin transporter-associated phenotypes.
The human serotonin (5-hydroxytryptamine, 5-HT) transporter (hSERT, SLC6A4) figures prominently in the etiology and treatment of many prevalent neurobehavioral disorders including anxiety, alcoholism, depression, autism, and obsessive-compulsive disorder (OCD). Here, we use naturally occurring polymorphisms in recombinant inbred (RI) lines to identify multiple phenotypes associated with altered...
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Recombinant inbred lines (RIL) derived from multiple inbred strains can serve as a powerful resource for the genetic dissection of complex traits. The use of such multiple-strain RIL requires a detailed knowledge of the haplotype structure in such lines. Broman (2005) derived the two- and three-point haplotype probabilities for 2(n)-way RIL; the former required hefty computation to infer the sy...
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The mouse is the most extensively used mammalian model for biomedical and aging research, and an extensive catalogue of laboratory resources is available to support research using mice: classical inbred lines, genetically modifi ed mice (knockouts, transgenics, and humanized mice), selectively bred lines, consomics, congenics, recombinant inbred panels, outbred and heterogeneous stocks, and an ...
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M A M M A L I A N ,&glucuronidase has been relatively well characterized with regard to such parameters as substrate specificity, tissue levels, pH dependence, intracellular localization, and protein structure. For a recent review the reader may consult LEVVY and CONCHIE (1966). Although this information failed to elucidate the physiolcigical role of glucuronidase, it has provided a convenient ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2009
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0809449106